Impaired mammary gland T cell population during early lactation in hypoprolactinemic lactation-deficient rats
نویسندگان
چکیده
منابع مشابه
Lactation Biology Symposium: Mammary gland biology revisited
The mammary gland goes through a coordinated series of developmental states during postnatal life in preparation for lactation. These changes ultimately reflect a changing endocrine environment alongside local alterations in the microenvironment. A longstanding assumption has been that estrogens serve as the first essential component for any of these developmental changes to be realized in the ...
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The delivery of copper to mammary gland and milk and the effects of lactation were examined in rats. Traces of (67)Cu/(64)Cu(II) were injected intraperitoneally or intravenously into virgin rats or lactating rats (2-5 days postpartum), and incorporation into blood, milk, and tissues was monitored. In virgin rats, most of the isotope first entered the liver and kidney. In lactating rats, almost ...
متن کاملFatty acid biosynthesis in rabbit mammary gland during pregnancy and early lactation.
The pattern of fatty acids synthesized by mammary-gland explants from rabbits during pregnancy and early lactation has been studied. From day 12 to day 18 of pregnancy, long-chain (C(14:0)-C(18:1)) fatty acids were the major products. From day 18 to day 21 of pregnancy there was an increase of up to 12-fold in the rate of fatty acid synthesis per unit wet weight of tissue that was almost exclus...
متن کاملImpaired mammary function and parathyroid hormone-related protein during lactation in growth-restricted spontaneously hypertensive rats.
Evidence implicates pivotal roles for parathyroid hormone-related protein (PTHrP) during lactation, including stimulation of mammary and pup growth. As spontaneously hypertensive rat (SHR) pups are growth restricted compared with the control Wistar Kyoto (WKY), we examined the relative roles of pup suckling and maternal lactational environment on pup growth, mammary PTHrP, and milk PTHrP and ca...
متن کاملElf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation.
Elf5 is an epithelial-specific ETS factor. Embryos with a null mutation in the Elf5 gene died before embryonic day 7.5, indicating that Elf5 is essential during mouse embryogenesis. Elf5 is also required for proliferation and differentiation of mouse mammary alveolar epithelial cells during pregnancy and lactation. The loss of one functional allele led to complete developmental arrest of the ma...
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ژورنال
عنوان ژورنال: REPRODUCTION
سال: 2013
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-12-0387